CD59 blockade enhances antigen-specific CD4+ T cell responses in humans: a new target for cancer immunotherapy?

نویسندگان

  • Baalasubramanian Sivasankar
  • M Paula Longhi
  • Kathleen M E Gallagher
  • Gareth J Betts
  • B Paul Morgan
  • Andrew J Godkin
  • Awen M Gallimore
چکیده

CD59, a broadly expressed GPI-anchored molecule, regulates formation of the membrane attack complex of the complement cascade. We previously demonstrated that mouse CD59 also down-modulates CD4(+) T cell activity in vivo. In this study, we explored the role of CD59 on human CD4(+) T cells. Our data demonstrate that CD59 is up-regulated on activated CD4(+) T cells and serves to down-modulate their activity in response to polyclonal and Ag-specific stimulation. The therapeutic potential of this finding was explored using T cells isolated from colorectal cancer patients. The findings were striking and indicated that blockade of CD59 significantly enhanced the CD4(+) T cell response to two different tumor Ags. These data highlight the potential for manipulating CD59 expression on T cells for boosting weak immune responses, such as those found in individuals with cancer.

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عنوان ژورنال:
  • Journal of immunology

دوره 182 9  شماره 

صفحات  -

تاریخ انتشار 2009